Electrophysiological Evidence for Spatial Hyperfocusing in Schizophrenia

Kreither, J., Lopez-Calderon, J., Leonard, C. J., Robinson, B. M., Ruffle, A., Hahn, B., Gold, J. M., & Luck, S. J. (2017). Electrophysiological Evidence for Spatial Hyperfocusing in SchizophreniaThe Journal of Neuroscience, 37, 3813-3823.

Double Oddball P3 Bar Graph.jpg

This paper from last spring describes new evidence for our hyperfocusing theory of cognitive dysfunction in schizophrenia.  Remarkably, we found that people with schizophrenia were actually better able to focus centrally and filter peripheral distractors than were control subjects. Under the right conditions, we even observed a (slightly) larger P3 wave in patients than in controls.